The Fast-Spreading New COVID-19 Subvariant XBB Is Part of a ‘New Class’ of Omicron
by by Korin Miller - Prevention.com on January 19, 2023The Fast-Spreading New COVID-19 Subvariant XBB Is Part of a ‘New Class’ of Omicron
Story by Korin Miller
For the past several months, Omicron subvariants BA.4 and BA.5 have dominated COVID-19 cases in the
XBB is getting a lot of buzz because it spreads fast—and seems to be able to evade immunity that people have built up from having a previous COVID-19 infection or getting the vaccine, says William Schaffner, M.D., an infectious disease specialist and professor at the Vanderbilt University School of Medicine. Still, Dr. Schaffner says, “it’s early days and we have a lot to learn.”
Here’s what we know about XBB so far, and why doctors are keeping a close eye on it.
What is the XBB COVID variant?
XBB is one of the “new class” of Omicron variants that are spreading fast right now, says Thomas Russo, M.D., professor and chief of infectious disease at the University at
“XBB is a hybrid version of two strains of the BA.2 form of Omicron,” explains Amesh A. Adalja, M.D., a senior scholar at the
The variant was first detected in August 2022 in
XBB is thought to have the best ability to evade antibody protections of these newly emerged COVID variants, according to a pre-print study from researchers in
Meaning, the vaccine and having previously had COVID-19 are not thought to offer the same level of protection against XBB as they have with previous strains of COVID-19. Antibody drugs like Evusheld and bebtelovimab may also not be very effective against XBB, the pre-print study says.
“These variants are evolving to evade protection,” Dr. Russo says. The bivalent booster is “likely going to be protective against severe disease” with XBB, but will be “imperfect against preventing infection," Dr. Russo says.
Don’t panic, though. “When it comes to evasion of vaccine protection, it’s important to recognize that vaccine protection is not all or none,” Dr. Adalja says. “Even with immune-evasive variants, vaccine protection against what matters most—severe disease—remains intact.”